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#bacteria

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This month's interesting facts about glycans - we take a look at "bacterial cellulose"! Yes you heard that correct! Cellulose is found all around us in the form of clothing, wood, paper products and is usually sourced from plants. But bacteria also produce a form of it.

Read more about it at: research.bidmc.org/ncfg/blog/f

For more interesting facts check out: research.bidmc.org/ncfg/intere

I recently found a study that shows the polyols encourage growth carcinogentic Strep. mutans, while Bacillus subtilus can break down polyols faster limiting their growth. You can get B. Subtilis from natti which is an aquired taste and texture, or from a probiotic pill. If you have #FODMAP issues you probably have a higher level of S. mutans than the average person. Just ordered some pills and pulled some natto out of the freezer. #microbiome #probiotics #bacteria #food #diet

Source: EBio Medicine, https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00460-2/fulltext

Summary
Background
To date, global priorities for new vaccine R&D have not been systematically identified for endemic pathogens. As part of Immunisation Agenda 2030 (IA2030), we have systematically identified priority endemic pathogens for new vaccine R&D based on country and regional stakeholder values to address this need.

Methods
MCDA surveys targeting policy makers and immunisation stakeholders in each World Health Organization (WHO) region were used to weight eight criteria for prioritisation. Applying those weights to regional pathogen data yielded regional top ten pathogen lists, which are intended to inform regional deliberations on R&D priorities. The regional top ten lists were combined into an IA2030 global priority list. To inform R&D, use cases for new vaccines and monoclonal antibodies were identified, then categorized in terms of the activities needed to accelerate progress.

Findings
In five out of six WHO regions, Annual deaths in children under five and Contribution to antimicrobial resistance were the most heavily weighted criteria. How participants weighted the criteria was not associated with their region, biographical characteristics, or areas of expertise. Five pathogens were common priorities across all regions: M tuberculosis, HIV-1, K pneumoniae, S aureus, and Extra-intestinal pathogenic E coli. Six pathogens were priorities in single regions. Combining regional top ten lists provided a global list of 17 priority pathogens for new vaccine R&D. Thirty-four distinct use cases were identified for new products targeting these pathogens. While most are in the “Advance product development” category, ten are in the “Research” category and seven are in the “Prepare to implement” category.

Interpretation
These priorities for new vaccine R&D will help stakeholders better respond to regional and country needs. The use cases will inform R&D and enable monitoring of R&D under IA2030.

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https://etidioh.wordpress.com/2024/11/05/identifying-who-global-priority-endemic-pathogens-for-vaccine-research-and-development-rd-using-multi-criteria-decision-analysis-mcda-an-objective-of-the-immunization-agenda-2030/

On the consequences of the wide-spread, systematic #destruction of #health facilities in #Gaza by #Israel, and some impossible "choices" it extorts from doctors and medical workers.

»A #baby who was very, very sick, needed to be on a #ventilator. After the baby passed away, what are we going to do with that ventilator? There is no way to sanitize the ventilator and get rid of that multidrug-resistant #bacteria. We also didn’t have tubing to change when we used the ventilator for another baby. So there is a very big chance that you’re going to spread the infection to other babies: so either the baby dies because there is no ventilator or the baby dies because of the bacterial infection. Your options were tragically limited.«

972mag.com/health-system-gaza-

+972 Magazine · A war on hospitals is a war on civilians: Israel’s fatal blow to health in GazaTwo documents outline the scale of destruction on Gaza’s health system and workers, threatening the possibility of sustaining life in the Strip.