為什麼有的人每天一包煙，活到90歲也沒得肺癌？
https://www.headline01.com/a/Y4C1STNmum7N8jgm6B5cYQ-8CDA2641.html
#肺癌
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#肺癌
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“我，27歲，肺癌晚期”：生命若可以重來，我一定遠離這個“殺手”
https://www.headline01.com/a/24VVUJiTTWD5j7FEb_agBw-55AD4D38.html
#晚期 #生命 #肺癌
新肺癌藥物試驗結果「離奇高」，醫師稱 | 肺癌 | 衛報
➤ 新肺癌藥物取得「離奇高」試驗結果
✤ https://www.theguardian.com/society/article/2024/may/31/trial-results-for-new-lung-cancer-drug-are-off-the-charts-say-doctors
醫師表示新藥的試驗結果具有非常出色的表現，在治療肺癌上取得前所未有的成果，有超過半數患有晚期疾病的患者在五年後仍然存活且疾病沒有進展。
+ 這個試驗結果確實帶來了對肺癌患者的希望，新藥的效果令人鼓舞。
+ 這項研究的成果對於癌症治療領域來說意義重大，希望能為更多的患者帶來更長的生存期。
#肺癌
The Guardian · Trial results for new lung cancer drug are ‘off the charts’, say doctors
六小時限時進食抑制肺癌進展並重塑晝夜節律代謝 | BMC Medicine | 全文
➤ 六小時限時進食抑制肺癌進展並重塑晝夜節律代謝
✤ https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03131-y
這項研究發現，六小時限時進食（TRF）不僅抑制肺癌的進展，還重塑了腫瘤中與糖酵解和晝夜節律相關的代謝物或基因的節律。研究還發現，TRF通過下調TIMELESS（TIM）基因的節律和隨後的自噬活化部分介導了抗腫瘤效應。結合TRF和TIM抑制進一步增強了抗腫瘤效果，與化療的治療效果相當。
+ 這項研究提供了一種新的方法來抑制肺癌的進展，並可能對肺癌的預防和治療有重要意義。
+ 這項研究的結果對於理解肺癌的發展機制以及開發新的治療策略具有重要價值。
#肺癌 #時間限制進食 #晝夜節律 #代謝
BioMed CentralSix-hour time-restricted feeding inhibits lung cancer progression and reshapes circadian metabolism - BMC MedicineBackground Accumulating evidence has suggested an oncogenic effect of diurnal disruption on cancer progression. To test whether targeting circadian rhythm by dietary strategy suppressed lung cancer progression, we adopted 6-h time-restricted feeding (TRF) paradigm to elucidate whether and how TRF impacts lung cancer progression. Methods This study used multiple lung cancer cell lines, two xenograft mouse models, and a chemical-treated mouse lung cancer model. Stable TIM-knockdown and TIM-overexpressing A549 cells were constructed. Cancer behaviors in vitro were determined by colony formation, EdU proliferation, wound healing, transwell migration, flow cytometer, and CCK8 assays. Immunofluorescence, pathology examinations, and targeted metabolomics were also used in tumor cells and tissues. mCherry-GFP-LC3 plasmid was used to detect autophagic flux. Results We found for the first time that compared to normal ad libitum feeding, 6-h TRF inhibited lung cancer progression and reprogrammed the rhythms of metabolites or genes involved in glycolysis and the circadian rhythm in tumors. After TRF intervention, only timeless (TIM) gene among five lung cancer-associated clock genes was found to consistently align rhythm of tumor cells to that of tumor tissues. Further, we demonstrated that the anti-tumor effect upon TRF was partially mediated by the rhythmic downregulation of the TIM and the subsequent activation of autophagy. Combining TRF with TIM inhibition further enhanced the anti-tumor effect, comparable to treatment efficacy of chemotherapy in xenograft model. Conclusions Six-hour TRF inhibits lung cancer progression and reshapes circadian metabolism, which is partially mediated by the rhythmic downregulation of the TIM and the subsequent upregulation of autophagy.